Open AccessREASSURING EFFECT OF PRAVASTATIN ON NATURAL KILLER CELL ACTIVITY IN STABLE RENAL TRANSPLANT PATIENTS
Author(s) -
L. M. B. Vaessen,
Paula P.M.C. van Miert,
Teun van Gelder,
Jan N. M. IJzermans,
Willem Weimar
Publication year - 2001
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/00007890-200104270-00028
Subject(s) - pravastatin , transplantation , medicine , cytotoxic t cell , cytotoxicity , natural killer cell , endocrinology , cholesterol , pharmacology , immunology , chemistry , in vitro , biochemistry
Administration of pravastatin soon after transplantation successfully lowers cholesterol levels, whereas a reduced number of acute rejection episodes is accompanied by a decrease in natural killer (NK) cell activity. As a consistent low NK cell activity caused by pravastatin might impair tumor surveillance leading to cancer, we studied the effect of pravastatin on NK cell activity in stable renal transplant patients.