Open AccessTOLERANCE TO MUSCULOSKELETAL ALLOGRAFTS WITH TRANSIENT LYMPHOCYTE CHIMERISM IN MINIATURE SWINE1
Author(s) -
Judy L. Bourget,
David W. Mathes,
G. Petur Nielsen,
Mark A. Randolph,
Yuzo Tanabe,
Vincent R. Ferrara,
Anette Wu,
Scott Arn,
David H. Sachs,
W. P.Andrew Lee
Publication year - 2001
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/00007890-200104150-00005
Subject(s) - immunosuppression , medicine , immune tolerance , microchimerism , transplantation , miniature swine , immunology , transplantation chimera , surgery , bone marrow , histocompatibility , haematopoiesis , antigen , hematopoietic cell , stem cell , biology , human leukocyte antigen , pregnancy , fetus , genetics
Although transplantation of musculoskeletal allografts in humans is technically feasible, the adverse effects of long-term immunosuppression subject the patient to high risks for correcting a non-life-threatening condition. Achieving immunologic tolerance to musculoskeletal allografts, without the need for chronic immunosuppression, could expand the clinical application of limb tissue allografting. Tolerance to musculoskeletal allografts has been accomplished previously in miniature swine in our laboratory. Although stable, mixed chimerism has been suggested as the mechanism underlying long-term tolerance in a rat limb model, the mechanism of this tolerance induction has not been established. This report explores the possible relationship between hematopoietic chimerism and tolerance to musculoskeletal allografts in swine.