Open AccessPROLONGATION OF ALLOGRAFT SURVIVAL WITH VIRAL IL-10 TRANSFECTION IN A HIGHLY HISTOINCOMPATIBLE MODEL OF RAT HEART ALLOGRAFT REJECTION1
Author(s) -
Xiao-Jing Zuo,
Charles Wang,
Dale Carpenter,
Yoshinori Okada,
Electra Nicolaidou,
Mieko Toyoda,
Alfredo Trento,
Stanley C. Jordan
Publication year - 2001
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/00007890-200103150-00020
Subject(s) - transfection , immunogenicity , medicine , recombinant dna , andrology , microbiology and biotechnology , immunology , biology , cell culture , gene , antibody , biochemistry , genetics
The ability to express genes with potential immunoregulatory capacity could reduce the immunogenicity of allografts and result in long-term graft survival. In this study, we examine the feasibility of transferring viral interleukin-10 (vIL-10) gene into rat hearts using adenovirus by intracoronary administration. The subsequent effects of delivered vIL-10 alone or with subtherapeutic doses of cyclosporine A (CsA) on parameters of allograft rejection (AR) were also examined.