Open AccessFULMINANT HEPATITIS BY Fas-LIGAND EXPRESSION IN MRL-lpr/lpr MICE GRAFTED WITH Fas-POSITIVE LIVERS AND WILD-TYPE MICE WITH Fas-MUTANT LIVERS1
Author(s) -
Xiao Kang Li,
Masayuki Fujino,
Atsushi Sugioka,
Miwa Morita,
Torayuki Okuyama,
Lei Guo,
Naoko Funeshima,
Hiroyuki Kimura,
Shin Enosawa,
Hiroshi Amemiya,
Seiichi Suzuki
Publication year - 2001
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/00007890-200102270-00004
Subject(s) - fas ligand , apoptosis , wild type , hepatocyte , immune system , liver transplantation , immunology , mutant , transfection , hepatitis b virus , medicine , transplantation , biology , virus , programmed cell death , cell culture , gene , in vitro , biochemistry , genetics
Fulminant hepatitis in mice could be induced by gene-transfection of Fas ligand (FasL). However, the mechanisms of this event still remain controversial as to whether it is mediated by direct Fas/FasL interaction and/or neutrophil migration. To investigate the role of exogenous FasL-expression, we established a simple but clear mouse model on which we performed liver transplantation between Fas-mutant mice (MRL-lpr/lpr) and wild-type mice (MRL+/+).