Open AccessBIOPHYSICAL CHARACTERISTICS OF ANTI-GALα1-3GAL IgM BINDING TO CELL SURFACES: IMPLICATIONS FOR XENOTRANSPLANTATION1
Author(s) -
William Parker,
Karyn B. Stitzenberg,
Paul B. Yu,
Valerie S. W. Pratt,
Yuko Nakamura,
Lily S. Farel,
Catherine Ward,
Song Lin,
Mary Lou Everett,
Jeffrey L. Platt
Publication year - 2001
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/00007890-200102150-00018
Subject(s) - antibody , epitope , chemistry , glycocalyx , biochemistry , cell , chaotropic agent , biology , immunology
Natural antibodies directed against cell surface carbohydrates are thought to be vital to host defense and to initiate the rejection of xenografts and ABO-incompatible allografts. The biophysical properties underlying the association and dissociation of these antibodies from cell surfaces is incompletely understood. We investigated those properties for the binding of Galalpha1-3Gal antibodies to porcine endothelial cell surfaces, because such interactions might be relevant to the clinical application of xenotransplantation.