Open Access“CHEMICAL PRECONDITIONING” BY 3-NITROPROPIONATE REDUCES ISCHEMIA-REPERFUSION INJURY IN CARDIAC-ARRESTED RAT LUNGS1
Author(s) -
Toshiki Hirata,
Tatsuo Fukuse,
Shinya Ishikawa,
Shinji Hanaoka,
Qing Chen,
Shōji Tanaka,
Hiromi Wada
Publication year - 2001
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/00007890-200102150-00003
Subject(s) - ischemia , medicine , pharmacology , ischemic preconditioning , mitochondrion , reperfusion injury , perfusion , anesthesia , lipid peroxidation , oxidative phosphorylation , lung , cardiology , chemistry , oxidative stress , biochemistry
Chemical preconditioning was defined as the induction of resistance to massive disruption of energy metabolism through prior chemical suppression of oxidative phosphorylation, by which phenomena similar to those resulting from increased ischemic tolerance as a result of ischemic preconditioning can be induced. It could be induced by the inhibitor of either mitochondrial complex I or II. We investigated whether or not chemical preconditioning by 3-nitropropionate (an inhibitor of the mitochondrial complex II) can suppress ischemia-reperfusion injury in cardiac-arrested lungs, which will be the major problem in lung transplants donated from non-heart-beating cadavers.