Open AccessTHE EFFECT OF APROTININ ON RENAL FUNCTION IN ORTHOTOPIC LIVER TRANSPLANTATION1
Author(s) -
I. Quintus Molenaar,
B. Begliomini,
G Grazi,
J. Ringers,
Terpstra Ot,
Robert J. Porte
Publication year - 2001
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/00007890-200101270-00014
Subject(s) - aprotinin , medicine , renal function , nephrotoxicity , perioperative , placebo , creatinine , urology , anesthesia , liver transplantation , dialysis , transplantation , surgery , kidney , alternative medicine , pathology
In the European Multicenter Study on the Use of Aprotinin in Liver Transplantation (EMSALT), a randomized, double-blind, placebo-controlled, prospective study, we demonstrated that aprotinin significantly reduces intraoperative blood loss during orthotopic liver transplantation (OLT). Aprotinin is metabolized in the kidney and potentially nephrotoxic at high concentrations. Renal insufficiency is a common and serious complication after OLT. It is unknown whether aprotinin increases the risk of renal failure after OLT.