Open AccessNITRIC OXIDE DIMINISHES APOPTOSIS AND p53 GENE EXPRESSION AFTER RENAL ISCHEMIA AND REPERFUSION INJURY1
Author(s) -
Gustavo Martínez-Mier,
Luis H. ToledoPereyra,
Stuart Bussell,
Jeff M. Gauvin,
Gary Vercruysse,
Amina Arab,
Jack R. Harkema,
James O. Jordan,
Peter A. Ward
Publication year - 2000
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/00007890-200011270-00006
Subject(s) - nitric oxide , blood urea nitrogen , creatinine , myeloperoxidase , apoptosis , kidney , sodium nitroprusside , ischemia , gene expression , medicine , pharmacology , endocrinology , renal function , chemistry , inflammation , biochemistry , gene
The role of nitric oxide in the ischemic injury of the kidney is still controversial. The aim of this study was to reevaluate the beneficial effect of exogenous nitric oxide and define its effects as regulator of gene p53 expression and apoptosis in the ischemic renal injury.