Open AccessNO EVIDENCE FOR INFECTION OF HUMAN CELLS WITH PORCINE ENDOGENOUS RETROVIRUS (PERV) AFTER EXPOSURE TO PORCINE FETAL NEURONAL CELLS1
Author(s) -
Jonathan Dinsmore,
Carolyn J. Manhart,
R. Raineri,
Douglas B. Jacoby,
Alan Moore
Publication year - 2000
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/00007890-200011150-00020
Subject(s) - fetus , transplantation , xenotransplantation , in vitro , biology , pathology , medicine , in vivo , andrology , immunology , pregnancy , biochemistry , genetics , microbiology and biotechnology
Recent demonstration of human cell infection in vitro with porcine endogenous retrovirus (PERV) has raised safety concerns for new therapies that involve transplantation of pig cells or organs to humans. To assess better the specific risk that may be associated with the transplantation of fetal pig neuronal cells to the central nervous system of patients suffering from intractable neurologic disorders (Parkinson's disease, Huntington's disease, and epilepsy), we have performed studies to determine whether there is evidence for in vivo or in vitro transmission of PERV from fetal pig neuronal cells to human cells.