Open AccessSUPPRESSION OF PRIMARY T-CELL RESPONSES AND INDUCTION OF ALLOANTIGEN-SPECIFIC HYPORESPONSIVENESS IN VITRO BY THE JANUS KINASE INHIBITOR TYRPHOSTIN AG4901
Author(s) -
Marcus D. Säemann,
Georg A. Böhmig,
Christoph H. Österreicher,
Günther Staffler,
Christos Diakos,
Peter-Michael Krieger,
Walter H. Hörl,
Hannes Stockinger,
Gerhard J. Zlabinger
Publication year - 2000
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/00007890-200010270-00016
Subject(s) - cd28 , il 2 receptor , cytokine , microbiology and biotechnology , tyrosine phosphorylation , ionomycin , t cell , janus kinase , biology , interleukin 2 , signal transduction , immunology , intracellular , immune system
Tyrphostin AG490 has recently been shown to block interleukin (IL)-2 receptor gamma-chain-associated Janus kinase 3. Here, we analyzed the effect of AG490 on T-cell alloresponses in vitro.