Open AccessMODULATION OF PULMONARY NA+ PUMP GENE EXPRESSION DURING COLD STORAGE AND REPERFUSION1
Author(s) -
Jong D. Kim,
Craig Baker,
Spencer I. Danto,
Vaughn A. Starnes,
Mark L. Barr
Publication year - 2000
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/00007890-200010150-00005
Subject(s) - viaspan , cold storage , atpase , reperfusion injury , messenger rna , pulmonary edema , chemistry , transplantation , lung , andrology , microbiology and biotechnology , medicine , ischemia , endocrinology , biology , enzyme , biochemistry , gene , horticulture
Reperfusion injury with pulmonary edema continues to be a major complication after lung transplantation. Alveolar fluid homeostasis is regulated by Na+/K+-ATPase activity on the basolateral surface of alveolar epithelial cells. Intact Na+/K+-ATPase is essential to the resolution of pulmonary edema. We characterized the effects of cold ischemia and reperfusion on expression of Na+/K+-ATPase mRNA and protein.