Open AccessA RAPID, SIMPLE, AND COST-EFFECTIVE METHOD FOR SCREENING LIVER PRESERVATION SOLUTIONS IN THE RAT1
Author(s) -
Renáta Smreková,
Katarı́na Vajdová,
M Kukan,
O Uličná,
Martina Lutterová,
L Wsólová,
J Horecký
Publication year - 2000
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/00007890-200008150-00007
Subject(s) - viaspan , washout , alanine transaminase , aspartate transaminase , perfusion , alkaline phosphatase , transaminase , chemistry , transplantation , liver transplantation , enzyme , hepatocyte , liver function , biochemistry , medicine , biology , in vitro , endocrinology
Rat liver transplantation models or isolated liver perfusion models are currently used for assessing efficacy of liver preservation methods. We tested the hypothesis that hepatocellular enzymes released into the washout solution after preservation may predict hepatic function during reperfusion and could thus be alternatively used for evaluating efficiency of liver preservation solutions. Furthermore, we applied this approach for assessing the role of Kupffer cells (KC) in preservation-induced liver damage.