Open AccessDIFFERENTIAL EFFECTS OF CYCLOSPORINE A, METHYLPREDNISOLONE, MYCOPHENOLATE, AND RAPAMYCIN ON CD154 INDUCTION AND REQUIREMENT FOR NF??B
Author(s) -
Stephen T. Smiley,
Vilmos Csizmadia,
Wei Gao,
Laurence A. Turka,
Wayne W. Hancock
Publication year - 2000
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/00007890-200008150-00005
Subject(s) - cd154 , cd40 , monoclonal antibody , pharmacology , medicine , transplantation , methylprednisolone , immunology , cancer research , in vitro , biology , cytotoxic t cell , antibody , biochemistry
Recent experimental data indicate that the targeting of the costimulatory molecule CD40-ligand (CD154) may well offer an opportunity for tolerance induction in transplant recipients and patients with autoimmune diseases, although the optimal therapeutic strategy for clinical application of CD154 monoclonal antibody (mAb) is unclear.