Open AccessGRAFT-VERSUS-LEUKEMIA EFFECT IN MINOR ANTIGEN MISMATCHED CHIMERAS GIVEN DELAYED DONOR LEUCOCYTE INFUSION: IMMUNOREGULATORY ASPECTS AND ROLE OF DONOR T AND ASGM1-POSITIVE CELLS1
Author(s) -
Hassan Sefrioui,
An Billiau,
Mark Waer
Publication year - 2000
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/00007890-200007270-00020
Subject(s) - minor histocompatibility antigen , cytotoxic t cell , chimera (genetics) , immunology , cd8 , leukemia , ctl* , bone marrow , spleen , antigen , transplantation , major histocompatibility complex , biology , microbiology and biotechnology , medicine , in vitro , biochemistry , gene
Previous studies have demonstrated that delayed donor leukocyte infusion (DLI) can increase graft-versus-leukemia (GVL) without increasing graft-versus-host-disease (GVHD) in MHC mismatched bone marrow (BM) chimeras. In our report, the immune status of minor antigen mismatched BM chimeras given DLI was studied. Particularly the role of donor ASGM1 positive or T cells in the graft-versus-leukemia effect (GVL) was investigated.