Open AccessHIGH-DOSE PORCINE HEMATOPOIETIC CELL TRANSPLANTATION COMBINED WITH CD40 LIGAND BLOCKADE IN BABOONS PREVENTS AN INDUCED ANTI-PIG HUMORAL RESPONSE
Author(s) -
Léo Bühler,
Michel Awwad,
M. Basker,
Satoshi Gojo,
Alan G. Watts,
S. Treter,
Kevin Nash,
G. Oravec,
Qing Chang,
Aron Thall,
Julian D. Down,
Megan Sykes,
David Andrews,
Robert Sackstein,
Mary E. WhiteScharf,
David H. Sachs,
D. K. C. Cooper
Publication year - 2000
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/00007890-200006150-00013
Subject(s) - transplantation , monoclonal antibody , immunology , miniature swine , biology , antibody , leukapheresis , haematopoiesis , total body irradiation , xenotransplantation , stem cell , medicine , cd34 , microbiology and biotechnology , chemotherapy , cyclophosphamide , genetics
In pig-to-primate organ transplantation, hyperacute rejection can be prevented, but the organ is rejected within days by acute vascular rejection, in which induced high-affinity anti-Gal alpha1-3Gal (alphaGal) IgG and possibly antibodies directed against new porcine (non-alphaGal) antigenic determinants are considered to play a major role. We have explored the role of an anti-CD40L monoclonal antibody in modifying the humoral response to porcine hematopoietic cells in baboons pretreated with a nonmyeloablative regimen.