Open AccessIMPROVED FIBRINOLYTIC CAPACITY AFTER WITHDRAWAL OF STEROID IMMUNOSUPPRESSION IN RENAL TRANSPLANT RECIPIENTS1
Author(s) -
Maria Teresa Sartori,
G Patrassi,
Paolo Rigotti,
Francesco Marchini,
Massimo Fioranelli,
Luca Spiezia,
Antonio Girolami
Publication year - 2000
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/00007890-200005270-00026
Subject(s) - immunosuppression , fibrinolysis , medicine , plasminogen activator , methylprednisolone , endocrinology , plasminogen activator inhibitor 1 , tissue plasminogen activator , t plasminogen activator , gastroenterology , immunology
Long-term steroid immunosuppression has been associated with the prothrombotic state observed in renal transplant (RT) patients, in whom both hypercoagulability due to an increase of von Willebrand factor/factor VIII complex, and impaired fibrinolysis due to PAI-1 excess have been demonstrated. Our aim was to investigate the effect of steroid withdrawal on fibrinolytic capacity in a group of RT patients.