Open AccessINCREASED EXPRESSION OF THE LYMPHOCYTE EARLY ACTIVATION MARKER CD69 IN PERIPHERAL BLOOD CORRELATES WITH HISTOLOGIC EVIDENCE OF CARDIAC ALLOGRAFT REJECTION1
Author(s) -
Kenneth O. Schowengerdt,
F. Jay Fricker,
Keith S. Bahjat,
Sean T. Kuntz
Publication year - 2000
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/00007890-200005270-00023
Subject(s) - cd8 , medicine , cd69 , lymphocyte , immune system , biopsy , heart transplantation , flow cytometry , cd3 , pathology , transplantation , immunology , lung transplantation , t cell , il 2 receptor
The human leukocyte membrane protein CD69 is an early activation marker induced in T lymphocytes, B cells, and natural killer cells in response to inflammatory stimuli. Cardiac catheterization and endomyocardial biopsy remain the "gold standard" for diagnosis of rejection after transplantation, and noninvasive methods of rejection surveillance have long been sought. We studied CD69 membrane protein expression in peripheral blood T lymphocytes obtained from pediatric cardiac transplant recipients at the time of biopsy and correlated the results with histologic rejection scores.