Open AccessHBV GENOTYPIC RESISTANCE TO LAMIVUDINE IN KIDNEY RECIPIENTS AND HEMODIALYZED PATIENTS
Author(s) -
Hélène Fontaine,
Valérie Thiers,
Yves Chrétien,
Hervé Zylberberg,
R Poupon,
Christian Bréchot,
Christophe Legendre,
Henri Kreis,
Stanislas Pol
Publication year - 2000
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/00007890-200005270-00020
Subject(s) - lamivudine , hepatitis b virus , virology , genotype , medicine , seroconversion , orthohepadnavirus , hepatitis b , hepadnaviridae , gastroenterology , virus , biology , genetics , gene
Lamivudine is a potent inhibitor of human immunodeficiency virus reverse transcriptase and hepatitis B virus (HBV) DNA polymerase. Its overall efficiency is clearly hampered by relapse at discontinuation and by risk of genotypic resistance. We describe herein the first cases of HBV resistance to lamivudine in kidney recipients and hemodialyzed patients.