Open AccessLOCAL SECRETION OF A CHIMERIC ANTI-CD4 ANTIBODY PROTECTS AGAINST GRAFT REJECTION IN THE NOD MOUSE1
Author(s) -
Andrew McKenzie,
Jamie L. Brady,
Roland Martinꝉ,
Harry M. Georgiou,
Andrew M. Lew
Publication year - 2000
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/00007890-200004270-00041
Subject(s) - transfection , nod , antibody , antigen , biology , immune system , secretion , microbiology and biotechnology , transplantation , t cell , immunology , cell culture , in vivo , medicine , endocrinology , genetics
Engineering a graft to secrete its own immunosuppressive antibodies may minimize the risks associated with current high dose systemic immunosuppression.