Open AccessCOMPARISON BETWEEN TACROLIMUS AND CYCLOSPORINE AS IMMUNOSUPPRESSIVE AGENTS COMPATIBLE WITH TOLERANCE INDUCTION BY CD4/CD8 BLOCKADE
Author(s) -
Moffatt Sd,
Metcalfe Sm
Publication year - 2000
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/00007890-200004270-00033
Subject(s) - tacrolimus , blockade , cd8 , pharmacology , medicine , monoclonal antibody , immunology , transplantation , antibody , receptor , immune system
Donor-specific tolerance can be induced in mice by transient antibody blockade of the CD4 and CD8 co-receptors of T cells. To evaluate the potential application of CD4/CD8 blockade in the clinic, we have asked if either tacrolimus or cyclosporine counteract the tolerogenic process.