Open AccessA COMPARISON OF FETAL AND ADULT PORCINE ISLETS WITH REGARD TO Gal?? (1,3)Gal EXPRESSION AND THE ROLE OF HUMAN IMMUNOGLOBULINS AND COMPLEMENT IN ISLET CELL CYTOTOXICITY1
Author(s) -
William Bennet,
Anna Björkland,
Berit Sundberg,
H.f.f.S. Davies,
Jining Liu,
Jan Holgersson,
Olle Korsgren
Publication year - 2000
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/00007890-200004270-00030
Subject(s) - islet , antibody , xenotransplantation , cytotoxicity , microbiology and biotechnology , fetus , incubation , biology , andrology , medicine , endocrinology , transplantation , chemistry , immunology , in vitro , biochemistry , diabetes mellitus , pregnancy , genetics
It is still debated whether fetal or adult porcine islets should be the preferred choice for future clinical islet xenotransplantation. Each type of islet preparation has advantages and disadvantages compared with the other. Here we present a direct comparison between fetal and adult porcine islets with regard to Gal alpha(1,3)Gal expression, immunoglobulin and complement binding, and cytotoxicity after exposure to fresh human serum.