Open AccessINDUCTION OF UNRESPONSIVENESS TO ISLET XENOGRAFT BY MMC TREATMENT OF GRAFT AND BLOCKAGE OF LFA-1/ICAM-1 PATHWAY1
Author(s) -
Tadeusz Grochowiecki,
Mitsukazu Gotoh,
Keizo Dono,
Yutaka Takeda,
Masato Sakon,
Hideo Yagita,
Ko Okumura,
Masayuki Miyasaka,
Morito Monden
Publication year - 2000
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/00007890-200004270-00008
Subject(s) - islet , icam 1 , medicine , cancer research , immunology , cell adhesion molecule , insulin
Induction of unresponsiveness to graft is one of major interest in xenotransplantation. Two different modalities [direct graft treatment by mitomycin C (MMC) and blockage of the lymphocyte function-associated antigen-1/intracellular adhesion molecule-1 (LFA-1/ICAM-1) pathway in recipients by species-specific mAbs] were tested for their ability to produce unresponsiveness to secondary islet xenografts.