Open AccessTRANSPLANTATION OF H-2KB-TRANSGENIC ADRENOCORTICAL CELLS IN THE MOUSE HAVING UNDERGONE AN ADRENALECTOMY
Author(s) -
Hendrik Seeliger,
Matthias Hoffmann,
Matthias Behrend,
Omke E. Teebken,
Thomas Tschernig,
Karel M. H. Philippens,
T. H. Schürmeyer,
Jürgen Klempnauer,
G. F. W. Scheumann
Publication year - 2000
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/00007890-200004270-00007
Subject(s) - corticosterone , transplantation , adrenalectomy , endocrinology , medicine , genetically modified mouse , adrenal cortex , transgene , biology , renal capsule , mhc class i , major histocompatibility complex , immunology , antigen , hormone , gene , biochemistry
A new model of cellular adrenocortical transplantation after bilateral adrenalectomy in the mouse was established. This model was used to study the effects of the expression of the transgenic MHC class I molecule H-2K(b) (Kb) on graft survival and morphologic features, corticosterone secretion, and the possibility of tolerance induction in the recipient.