Open AccessTHE EFFECT OF POLYMORPHISMS IN TUMOR NECROSIS FACTOR-??, INTERLEUKIN-10, AND TRANSFORMING GROWTH FACTOR-??1 GENES IN ACUTE HEPATIC ALLOGRAFT REJECTION
Author(s) -
Andrew Bathgate,
Vera Pravica,
Chris Perrey,
George Therapondos,
John Plevris,
Peter Hayes,
Ian V. Hutchinson
Publication year - 2000
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/00007890-200004150-00054
Subject(s) - tumor necrosis factor alpha , genotype , liver transplantation , transforming growth factor , cytokine , immunology , medicine , interleukin , transplantation , necrosis , polymerase chain reaction , interleukin 6 , gene , biology , pathology , genetics
The occurrence of acute rejection in orthotopic liver transplantation is unpredictable. The role of cytokines in the process of rejection is not entirely clear. We investigated polymorphisms in the genes encoding tumor necrosis factor (TNF)-alpha, interleukin (IL)-10, and transforming growth factor (TGF)-beta1, which affect the amount of cytokine produced in vitro, in a liver transplant population to determine any association with acute rejection.