Open AccessA DENDRITIC CELL LINE GENETICALLY MODIFIED TO EXPRESS CTLA4-IG AS A MEANS TO PROLONG ISLET ALLOGRAFT SURVIVAL12
Author(s) -
Robert W. O’Rourke,
⋅Sang-Mo Kang,
Jennifer A. Lower,
Sandy Feng,
Nancy L. Ascher,
Steinunn Baekkeskov,
Peter Stock
Publication year - 2000
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/00007890-200004150-00039
Subject(s) - islet , dendritic cell , transfection , transplantation , immunology , antigen , genetically modified organism , medicine , biology , cell culture , endocrinology , gene , diabetes mellitus , biochemistry , genetics
Dendritic cells are potent antigen-presenting cells that bind allogeneic T cells. They are thus candidates for targeting immunoregulatory molecules to the alloreactive T cell compartment and suppressing the alloimmune response.