Open AccessTGF-?? EXPRESSION IN RENAL TRANSPLANT BIOPSIES
Author(s) -
Mostafa Mohamed,
Helen Lee Robertson,
Trevor Booth,
S. Balupuri,
John A. Kirby,
David Talbot
Publication year - 2000
Publication title -
transplantation
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/00007890-200003150-00059
Subject(s) - biopsy , medicine , renal biopsy , kidney , transplantation , kidney disease , kidney transplantation , skin biopsy , pathology , renal function , tacrolimus , transforming growth factor beta , nephrology , transforming growth factor , urology
Chronic rejection is a major cause of graft dysfunction after kidney transplantation. This fibroproliferative disease may be promoted by overproduction of transforming growth factor beta (TGF-beta). Previous studies have suggested that CsA might increase production of this growth factor. The current study was designed to measure the expression of TGF-beta(b) in renal transplant biopsy specimens from patients undergoing immunosuppressive therapy with either CsA or tacrolimus (FK506).