Open Accessp53 CODON 72 POLYMORPHISM AND SUSCEPTIBILITY TO SKIN CANCER AFTER RENAL TRANSPLANTATION
Author(s) -
Sara E. Marshall,
Cristina Bordea,
Fenella Wojnarowska,
Peter J. Morris,
Ken I. Welsh
Publication year - 2000
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/00007890-200003150-00056
Subject(s) - genotype , transplantation , carcinogenesis , allele , biology , cancer research , immunology , gene , genetics , medicine
Infection with human papillomavirus (HPV) is an important risk factor for the development of skin cancer after renal transplantation. It has recently been suggested that degradation of the tumor suppressor gene p53 is an important mechanism for human papillomavirus-induced carcinogenesis. A common genomic polymorphism occurs at codon 72 of the p53 gene, and in vitro the codon 72Arg variant appears to be particularly susceptible to degradation.