Open AccessASSOCIATION OF GLUCOCORTICOIDS AND CYCLOSPORIN A OR RAPAMYCIN PREVENTS E-SELECTIN AND IL-8 EXPRESSION DURING LPS- AND TNF??-MEDIATED ENDOTHELIAL CELL ACTIVATION1
Author(s) -
Béatrice Charreau,
Stéphanie Coupel,
Françoise Goret,
Christine Pourcel,
JeanPaul Soulillou
Publication year - 2000
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/00007890-200003150-00047
Subject(s) - e selectin , tumor necrosis factor alpha , endothelial stem cell , medicine , immunology , cell , chemistry , cell adhesion , biochemistry , in vitro
Endothelial cell (EC) activation plays an important role in inflammation, hemostasis, and organ rejection of allogeneic and xenogeneic transplantation. These processes leads to rapid and transient up-regulation of proinflammatory molecules, such as the adhesion molecule E-selectin and the chemotactic cytokine IL-8. The purpose of this study was to investigate the specific effects of several major and potentially synergistic immunosuppressive drugs-cyclosporin A (CsA), rapamycin (Rap), and glucocorticoids (GC)-on lipopolysaccharide (LPS)- or tumor necrosis factor (TNF)alpha-induced EC activation