Open AccessMYCOPHENOLIC ACID-INDUCED GTP DEPLETION ALSO AFFECTS ATP AND PYRIMIDINE SYNTHESIS IN MITOGEN-STIMULATED PRIMARY HUMAN T-LYMPHOCYTES1
Author(s) -
Yu Qiu,
L D Fairbanks,
K Rückermann,
C M Hawrlowicz,
David F. Richards,
Bernhard J. Kirschbaum,
H. Anne Simmonds
Publication year - 2000
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/00007890-200003150-00038
Subject(s) - gtp' , mycophenolic acid , purine , biochemistry , pyrimidine metabolism , hypoxanthine , nucleotide , uridine , chemistry , de novo synthesis , uracil , dna synthesis , biology , transplantation , in vitro , enzyme , medicine , dna , rna , gene
Mycophenolate mofetil (MMF) is an effective immunosuppressant developed for use in organ transplantation. It specifically targets lymphocyte purine biosynthesis. However, side effects do occur. Understanding how the active metabolite of MMF, mycophenolic acid (MPA) affects the normally integrated interaction between intracellular purine and pyrimidine pathways might aid the development of improved therapeutic regimes.