Open AccessN-ACETYL-L-CYSTEINE FOR PREVENTING LUNG REPERFUSION INJURY AFTER LIVER ISCHEMIA-REPERFUSION
Author(s) -
Avi A. Weinbroum,
Valery Rudick,
Ron BenAbraham,
Ela Karchevski
Publication year - 2000
Publication title -
transplantation
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/00007890-200003150-00031
Subject(s) - lung , liver transplantation , lung transplantation , bronchoalveolar lavage , reperfusion injury , medicine , glutathione , ischemia , transplantation , pulmonary artery , anesthesia , pharmacology , pathology , chemistry , biochemistry , enzyme
Acute lung reperfusion injury (ALI) frequently follows an ischemic event in another organ, such as organ transplantation. We recently demonstrated that lung priming with N-acetyl-L-cysteine (NAC) prevented liver ischemia-reperfusion (IR)-induced ALI pending on reduced glutathione (GSH) amount of replenishment. We now assessed the therapeutic effect of NAC-in preventing ALI caused by liver IR-if administered to the lung during liver reperfusion.