Open AccessA SURFACE-BOUND FORM OF HUMAN C1 ESTERASE INHIBITOR IMPROVES XENOGRAFT REJECTION1
Author(s) -
Katsuyoshi Matsunami,
Shuji Miyagawa,
Mako Yamada,
Masao Yoshitatsu,
R Shirakura
Publication year - 2000
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/00007890-200003150-00013
Subject(s) - chinese hamster ovary cell , transfection , decay accelerating factor , cd59 , cd46 , complement system , microbiology and biotechnology , pi , phospholipase c , cell culture , phosphatidylinositol , chemistry , biology , biochemistry , antibody , enzyme , gene , receptor , immunology , signal transduction , genetics
The purpose of the present study was to investigate the effect of the C1 esterase inhibitor (C1-INH) molecule against human complement attack on a swine endothelial cell (SEC) membrane. Human C1-INH functions as an inhibitor for complement reaction in the first step of the classical pathway in the fluid phase.