Open AccessALLEVIATION OF GRAFT-VERSUS-HOST DISEASE AFTER CONDITIONING WITH COBALT-PROTOPORPHYRIN, AN INDUCER OF HEME OXYGENASE-1
Author(s) -
Jacky Woo,
Suhasini Iyer,
Nancy Mori,
Roland Buelow
Publication year - 2000
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/00007890-200002270-00026
Subject(s) - copp , splenocyte , spleen , immunology , medicine , heme oxygenase , lymphocyte , immune system , inducer , biology , heme , biochemistry , enzyme , gene
Recently, we demonstrated that elevated expression of heme oxygenase-1 (HO-1 or Hsp-32) resulted in the modulation of several immune effector functions. Here we evaluated whether induction of HO-1 after administration of cobalt protoporphyrin (CoPP) can prevent the development of acute graft-versus-host-disease (GVHD).