Open AccessIG-THERASORB IMMUNOAPHERESIS IN ORTHOTOPIC XENOTRANSPLANTATION OF BABOONS WITH LANDRACE PIG HEARTS 1,2
Author(s) -
Paolo Brenner,
Hermann Reichenspurner,
Michael Schmoeckel,
Cornelius Wimmer,
A. Rucker,
Veronika Eder,
Bruno Meiser,
Michael Hinz,
Thomas W. Felbinger,
Josef MüllerHöcker,
C. Hammer,
B. Reichart
Publication year - 2000
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/00007890-200001270-00003
Subject(s) - xenotransplantation , miniature swine , immunoadsorption , antibody , baboon , heart transplantation , polyclonal antibodies , transplantation , complement system , miniature pig , medicine , extracorporeal circulation , pathology , andrology , biology , immunology , surgery
The major problem of xenotransplantation is, that hyperacute xenograft rejection (HXR) causes graft failure within minutes or a few hours because of natural antibodies and activation of the complement system. As a preclinical model we transplanted pig hearts orthotopically into baboons. To prevent HXR after orthotopic xenotransplantation (oXHTx), the immunoglobulins (Ig) and natural antibodies were adsorbed to reusable Ig-Therasorb immunoadsorption (IA) columns.