Open AccessASSOCIATION BETWEEN CYTOMEGALOVIRUS DISEASE AND CHRONIC REJECTION IN KIDNEY TRANSPLANT RECIPIENTS1
Author(s) -
Abhinav Humar,
Kristen J. Gillingham,
William D. Payne,
David L. Dünn,
David E.R. Sutherland,
Arthur J. Matas
Publication year - 1999
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/00007890-199912270-00011
Subject(s) - medicine , cytomegalovirus , betaherpesvirinae , pathogenesis , disease , risk factor , relative risk , immunology , incidence (geometry) , gastroenterology , transplantation , kidney disease , human cytomegalovirus , viral disease , virus , herpesviridae , confidence interval , physics , optics
It has long been suggested that cytomegalovirus (CMV) disease plays a role in the pathogenesis of chronic rejection (CR). However, its role has been difficult to prove, given the strong association between acute rejection and CMV, and the even stronger association between acute rejection and CR. To try to isolate the relative contribution of CMV infection in the pathogenesis of CR, we used multivariate techniques to examine risk factors for CR, including CMV disease.