Open AccessIL-10/Fc INHIBITS MACROPHAGE FUNCTION AND PROLONGS PANCREATIC ISLET XENOGRAFT SURVIVAL1
Author(s) -
Ximin Feng,
Xin Xiao Zheng,
Shounan Yi,
Anne M. Lehnert,
Terry B. Strom,
Philip J. O’Connell
Publication year - 1999
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/00007890-199912150-00023
Subject(s) - islet , macrophage , transplantation , tumor necrosis factor alpha , in vivo , cytokine , splenocyte , interleukin 10 , immune system , immunology , pancreatic islets , cancer research , medicine , endocrinology , chemistry , biology , in vitro , insulin , microbiology and biotechnology , biochemistry
Xenograft rejection is a complex response in which macrophages and other effector cells are activated by CD4+ T cells. Initiation and regulation of this response is in part mediated by cytokines. In this study we test the hypothesis that xenograft destruction is an interleukin- (IL) 10 responsive, macrophage-mediated event.