Open AccessLONG-TERM OUTCOME AND ALLOANTIBODY PRODUCTION IN A NON-MYELOABLATIVE REGIMEN FOR INDUCTION OF RENAL ALLOGRAFT TOLERANCE1
Author(s) -
Tatsuo Kawai,
Alain Poncelet,
David H. Sachs,
Shamila Mauiyyedi,
S Bosković,
S. Wee,
Dicken S.C. Ko,
Amelia Bartholomew,
Masaaki Kimikawa,
Han Zhou Hong,
Gregory A Abrahamian,
Robert B. Colvin,
A. Benedict Cosimi
Publication year - 1999
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/00007890-199912150-00022
Subject(s) - medicine , splenectomy , transplantation , immunosuppression , regimen , kidney transplantation , kidney , total body irradiation , gastroenterology , surgery , urology , spleen , cyclophosphamide , chemotherapy
Multilineage chimerism and long-term acceptance of renal allografts has been produced in non-human primates conditioned with a nonmyeloablative regimen. Our study was undertaken to evaluate the immunological and pathological status of long-term survivors and to define the role of splenectomy and of the primarily vascularized kidney in the regimen.