Open AccessPROLONGATION OF SKIN ALLOGRAFT SURVIVAL IS ASSOCIATED WITH REDUCED Th1 CYTOKINE RESPONSES IN THE WKY???F344 RAT MODEL
Author(s) -
Electra Nicolaidou,
Yoshinori Okada,
Xiao-Jing Zuo,
Mieko Toyoda,
Alberto M. Marchevsky,
Jack M. Matloff,
Stanley C. Jordan
Publication year - 1999
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/00007890-199911150-00028
Subject(s) - lymph , cytokine , lung , skin grafting , infiltration (hvac) , cd8 , pathology , transplantation , medicine , interleukin , immunohistochemistry , cellular infiltration , immunology , immune system , inflammation , surgery , physics , thermodynamics
We have reported previously that F344 rats develop a spontaneous tolerance to WKY lung allografts and show long-term retention of donor-specific skin grafts placed 35 days after lung transplantation. In this study, we investigated the immunologic mechanisms that may be responsible for the prolonged skin graft survival in animals tolerized with lung allografts.