Open AccessRESISTANCE OF ESTABLISHED PORCINE ISLET XENOGRAFTS TO HUMORAL REJECTION BY HYPERIMMUNE SERA
Author(s) -
William A. Gourlay,
John J. O’Neil,
Wayne W. Hancock,
Anthony P. Monaco,
Takashi Maki
Publication year - 1999
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/00007890-199909270-00023
Subject(s) - islet , antibody , xenotransplantation , antigen , transplantation , streptozotocin , monoclonal antibody , immune system , immunology , biology , microbiology and biotechnology , medicine , endocrinology , diabetes mellitus
Although preformed natural antibodies cause hyperacute rejection of primarily vascularized xenografts, tissue grafts such as skin or islets are revascularized by in-growth of host capillaries and therefore might be resistant to circulating antibodies. We examined the effect of hyperimmune serum and primed T cells on the survival of long-term porcine islet xenografts in diabetic nude mice.