Open AccessCD34+ SELECTED BONE MARROW GRAFTS ARE RADIOPROTECTIVE AND ESTABLISH MIXED CHIMERISM IN DOGS GIVEN HIGH DOSE TOTAL BODY IRRADIATION1
Author(s) -
Benedetto Bruno,
Richard A. Nash,
Philip M. Wallace,
M. John Gass,
Jennifer Thompson,
Rainer Storb,
PA McSweeney
Publication year - 1999
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/00007890-199908150-00004
Subject(s) - cd34 , bone marrow , haematopoiesis , stem cell , progenitor cell , transplantation , biology , immunology , andrology , medicine , microbiology and biotechnology
Canine stem cell transplantation models have provided important preclinical information for human clinical studies. The recent cloning of cDNA for canine CD34 and the production of monoclonal antibodies that recognize canine CD34 have been the basis for the development of techniques for the large-scale enrichment of canine hematopoietic progenitor cells. In this study, we evaluated the in vivo functional properties of canine bone marrow CD34+ cells after a myeloablative conditioning regimen.