Open AccessASSOCIATION OF LAMIVUDINE RESISTANCE IN RECURRENT HEPATITIS B AFTER LIVER TRANSPLANTATION WITH ADVANCED HEPATIC FIBROSIS
Author(s) -
Ziv BenAri,
Orit Pappo,
Romy Zemel,
E. Mor,
Ran TurKaspa
Publication year - 1999
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/00007890-199907270-00012
Subject(s) - lamivudine , medicine , liver transplantation , hepatitis b virus , gastroenterology , liver biopsy , nucleoside analogue , hepatitis b , transplantation , virology , biopsy , virus , biology , nucleoside , biochemistry
Orthotopic liver transplantation (OLT) in patients with hepatitis B virus (HBV) infection is known to be associated with a high recurrence rate and poor prognosis. Lamivudine, a nucleoside analogue, is a potent inhibitor of HBV replication, but it is associated with a 14-39% rate of resistance.