Open AccessTRANSFORMING GROWTH FACTOR (TGF)-?? MIMICS AND ANTI-TGF-?? ANTIBODY ABROGATES THE IN VIVO EFFECTS OF CYCLOSPORINE
Author(s) -
Ashwani Khanna,
Victor Cairns,
Carl G. Becker,
Jeffrey D. Hosenpud
Publication year - 1999
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/00007890-199903270-00016
Subject(s) - in vivo , transforming growth factor , ex vivo , transforming growth factor beta , endocrinology , medicine , chemistry , pharmacology , biology , microbiology and biotechnology
Cyclosporine (CsA) has been shown to induce the expression of transforming growth factor (TGF)-beta both in vitro and in vivo. It is hypothesized that the efficacy as well as the side effects of CsA are mediated by TGF-beta. This study was planned to investigate whether anti-TGF-beta mitigated and TGF-beta reproduced the in vivo effects of CsA to directly prove this hypothesis.