Open AccessFETAL PORCINE ISLET-LIKE CELL CLUSTERS TRANSPLANTED TO CYNOMOLGUS MONKEYS
Author(s) -
Johan Söderlund,
Lars Wennberg,
Esmeralda CastañosVélez,
Peter Biberfeld,
Shuguang Zhu,
Annika Tibell,
C. G. Groth,
Olle Korsgren
Publication year - 1999
Publication title -
transplantation
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/00007890-199903270-00002
Subject(s) - transplantation , xenotransplantation , cellular infiltration , renal capsule , islet , immunosuppression , pathology , medicine , antibody , infiltration (hvac) , kidney , mononuclear cell infiltration , fetus , necrosis , andrology , cd68 , immunohistochemistry , immunology , biology , endocrinology , inflammation , diabetes mellitus , pregnancy , physics , genetics , thermodynamics
The mechanism(s) involved in acute cellular xenograft rejection have hitherto been generated in vitro or in different experimental models, with pig tissue being transplanted to rodents. There is an urgent need to validate these results in a clinically more relevant combination of species.