Open AccessEFFECT OF SYSTEMIC CYCLOSPORINE ON TUMOR RECURRENCE AFTER LIVER TRANSPLANTATION IN A MODEL OF HEPATOCELLULAR CARCINOMA1
Author(s) -
Chris E. Freise,
Linda D. Ferrell,
Tao Liu,
Nancy L. Ascher,
John P. Roberts
Publication year - 1999
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/00007890-199902270-00003
Subject(s) - medicine , immunosuppression , hepatocellular carcinoma , transplantation , liver transplantation , saline , gastroenterology , survival rate , surgery , adverse effect , urology
Long-term results after liver transplantation for hepatocellular carcinoma have been disappointing, largely because of the high recurrence rate. It is controversial whether the immunosuppressed state of the recipient contributes to this recurrence rate. We have developed a model in the rat system to examine the effect of immunosuppression on tumor recurrence after transplantation, as well as to evaluate other treatment strategies to decrease the recurrence rate.