Open AccessCD4+ CELLS PLAY A MAJOR ROLE IN XENOGENEIC HUMAN ANTI-PIG CYTOTOXICITY THROUGH THE FAS/FAS LIGAND LYTIC PATHWAY1,2
Author(s) -
Shounan Yi,
Ximin Feng,
Y Wang,
Thomas W. H. Kay,
Philip J. O’Connell
Publication year - 1999
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/00007890-199902150-00017
Subject(s) - fas ligand , microbiology and biotechnology , cytotoxicity , cytotoxic t cell , biology , cd8 , peripheral blood mononuclear cell , t cell , apoptosis , granzyme , antigen , perforin , immunology , immune system , in vitro , programmed cell death , biochemistry
In this study, the role of cell-mediated cytotoxicity by human leukocytes against pig endothelial cells was examined in vitro. The aim was to determine which cell subsets were responsible for this phenomenon and which pathways were involved in cell lysis.