Open AccessHLA-G EXPRESSION PROTECTS PORCINE ENDOTHELIAL CELLS AGAINST NATURAL KILLER CELL-MEDIATED XENOGENEIC CYTOTOXICITY1,2
Author(s) -
Hajime Sasaki,
Xiao Xu,
Douglas M. Smith,
Todd K. Howard,
T. Mohanakumar
Publication year - 1999
Publication title -
transplantation
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/00007890-199901150-00005
Subject(s) - xenotransplantation , transfection , human leukocyte antigen , microbiology and biotechnology , hla g , polyclonal antibodies , biology , antibody , lymphokine activated killer cell , cytotoxicity , cell culture , natural killer cell , transplantation , immunology , antigen , immune system , t cell , interleukin 21 , in vitro , medicine , biochemistry , surgery , genetics
Natural killer (NK) cells are major component of the cellular response in xenotransplantation. NK cell activation and NK cell-mediated cytotoxicity can be a direct barrier to the potential use of xenogeneic organs in human transplantation.