Open AccessDONOR RESTING B CELLS INDUCE INDEFINITE PROLONGATION OF FULLY ALLOGENEIC CARDIAC GRAFTS WHEN DELIVERED WITH ANTI-IMMUNOGLOBULIN-D MONOCLONAL ANTIBODY
Author(s) -
Masanori Niimi,
Masaki Hara,
Oliver Witzke,
Peter J. Morris,
Kathryn J. Wood
Publication year - 1998
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/00007890-199812270-00037
Subject(s) - antigen , immunoglobulin d , monoclonal antibody , immunology , transplantation , antibody , in vivo , monoclonal , b cell , major histocompatibility complex , medicine , microbiology and biotechnology , biology
Resting B (rB) cells have been shown to induce T-cell anergy in vitro and to prolong the survival of skin and cardiac grafts mismatched for minor histocompatibility antigens. However, rB cells were unable to modulate the rejection response when grafts mismatched for major histocompatibility complex antigens were transplanted. We reasoned that donor antigens, which presented via the indirect pathway by recipient antigen-presenting cells, in particular B cells, might influence the ability of rB cells to induce unresponsiveness. To explore this hypothesis, we used an anti-immunoglobulin (Ig)-D monoclonal antibody (mAb) specific for recipient B cells to deplete these cells, thereby decreasing the potential for indirect presentation in vivo.