Open AccessROLE OF DONOR AND RECIPIENT ANTIGEN-PRESENTING CELLS IN PRIMING AND MAINTAINING T CELLS WITH INDIRECT ALLOSPECIFICITY1
Author(s) -
Loredana Frasca,
Alessandra Amendola,
Philip Hornick,
Paul Brookes,
Gerald Aichinger,
Federica M. MarelliBerg,
Robert I. Lechler,
Giovanna Lombardi
Publication year - 1998
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/00007890-199811150-00020
Subject(s) - priming (agriculture) , major histocompatibility complex , immunology , antigen , human leukocyte antigen , biology , antigen presenting cell , t cell , transplantation , antigen presentation , context (archaeology) , histocompatibility , epitope , streptamer , immune system , medicine , paleontology , botany , germination
It has been suggested that the sensitization of recipient T lymphocytes against peptides derived from allogeneic major histocompatibility complex (MHC) antigens in the context of self-MHC molecules may contribute to the pathogenesis of chronic allograft rejection. The purpose of this study was to quantitate and characterize the indirect alloresponse in renal transplantation.