Open AccessSERIOUS INTERACTION BETWEEN MIBEFRADIL AND TACROLIMUS1
Author(s) -
Stephan Krähenbühl,
Andrea Menafoglio,
Emile Giostra,
Augusto Gallino
Publication year - 1998
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/00007890-199810270-00026
Subject(s) - mibefradil , tacrolimus , diltiazem , medicine , pharmacology , drug interaction , nifedipine , therapeutic drug monitoring , pharmacokinetics , transplantation , calcium , voltage dependent calcium channel
Tacrolimus is metabolized by cytochrome P450 3A4 and 2D6 and has a narrow therapeutic range. We report a serious kinetic interaction between tacrolimus and mibefradil, a potent cytochrome P450 inhibitor.