Open AccessCOMPLEMENT INHIBITION BY SOLUBLE COMPLEMENT RECEPTOR TYPE 1 IMPROVES MICROCIRCULATION AFTER RAT LIVER TRANSPLANTATION1,2
Author(s) -
Thorsten G. Lehmann,
Thomas A. Koeppel,
Michael Kirschfink,
Martha-Maria Gebhard,
Christian Herfarth,
Gerd Otto,
Stefan Post
Publication year - 1998
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/00007890-199809270-00005
Subject(s) - complement receptor 1 , kupffer cell , complement system , microcirculation , liver transplantation , perfusion , complement component 5 , transplantation , ischemia , complement receptor , endothelial stem cell , medicine , reperfusion injury , parenchyma , liver injury , receptor , in vivo , inflammation , pathology , immunology , biology , in vitro , antibody , biochemistry , microbiology and biotechnology
Recent observations provide evidence that complement is involved in the pathophysiology of ischemia/reperfusion injury. In this study, we assessed the impact of complement inhibition on hepatic microcirculation and graft function using a rat model of liver transplantation.