Open AccessSQUAMOUS CELL CARCINOMAS AFTER ALLOGENEIC BONE MARROW TRANSPLANTATION FOR APLASTIC ANEMIA
Author(s) -
Gèrard Socié,
Catherine Scieux,
Éliane Gluckman,
Thierry Soussi,
Christine Clavel,
PierreJean Saulnier,
P Birembault,
J Bosq,
F. Morinet,
Anne Janin
Publication year - 1998
Publication title -
transplantation
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/00007890-199809150-00023
Subject(s) - aplastic anemia , fanconi anemia , medicine , transplantation , virus , bone marrow failure , immunology , population , anemia , antibody , bone marrow , pathology , biology , gene , dna repair , stem cell , haematopoiesis , biochemistry , genetics , environmental health
Secondary solid tumors are rare events occurring in patients who underwent allogeneic marrow transplantation for aplastic anemia and Fanconi's anemia. Human herpes virus 8 (HHV8), Epstein-Barr virus (EBV), and human papillomaviruses (HPV) sequences have been found in squamous cell carcinoma (SCC) occurring in organ transplant recipients. The tumor suppressor gene p53 has been strongly linked to the occurrence of SCC in the nonimmunocompromised population.